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Epigenetic modifications affecting long-term gene expression DNA methylation changes: GHK-Cu may affect DNA methyltransferase activity altering cytosine methylation patterns

Result:Showed no signs of testicular toxicity, and only adaptive changes in the liver due to cytochrome P450 induction which were not judged adverse, providing a 200 fold margin between the no adverse effect level and the predicted human exposure at the predicted therapeutic dose

References Demir S, Nawroth PP, Herzig S, Ekim Ustunel B

Foods to prioritise include: Berries such as blueberries, raspberries, and strawberries Olive oil and oily fish, which contain omega-3 fatty acids Turmeric extract, which contains curcumin Green tea, which is rich in catechins Vitamin C-rich foods such as citrus fruits and peppers Exercise regularly Regular exercise has been shown to boost glutathione production and improve antioxidant defences

Frontiers of medicine

However, a targeted disruption of igf1 expression in mouse chondrocytes reduced bone length (222)